Yinfa Ma

Curators' Teaching Professor

320 Schrenk Hall
Missouri University of Science and Technology
Rolla, MO 65409-0010
(573) 341-6220
Fax: (573) 341-6033

Zhengzhou University, China, B.S., 1981

Iowa State University, Ph.D., 1990. Analytical Chemistry

Iowa State University, Research Scientist, 1999-2000




This research group focuses on environmental analysis, bio-analysis and bio-separations, including environmental contaminants, toxins, DNAs, proteins, peptides, amino acids, small molecules, cancer markers and other biological compounds.  Research is conducted using high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), high performance capillary electrophoresis (HPCE), GC-MS, HPLC-MS, HPCE-MS, gel electrophoresis, and size-exclusion chromatography, in an attempt to develop new bioanalytical instrumentation and procedures. Laser spectroscopy, standard "wet" chemistry plus the extensive use of personal computers for data collection and data processing are also incorporated into all of the research projects.  In addition, we have focused on precancer screening for the past several years and will continue with this research project in the years to come. Precancer screening at the single molecular level is our eventual goal. 



Casey Burton, Honglan Shi, Yinfa Ma, “Daily Variation and Effect of Dietary Folate on Urinary Pteridines”, Metabolomics, 2016, 12(5):1-10.

Danielle West, Qihua Wu, Ariel Donovan, Honglan Shi (corresponding author), Yinfa Ma, Hua Jiang, Jianmin Wang. “N-Nitrosamine Formation by Monochloramine, Free Chlorine, and Peracetic Acid Disinfection with Presence of Amine Precursors in Drinking Water System” Chemosphere, 2016, 153: 521-527.

Ariel R. Donovan, Craig D. Adams, Yinfa Ma, Chady Stephan, Todd Eichholz, Honglan Shi, “Single Particle ICP-MS Characterization of TiO2, Ag, and Au Nanoparticles during Drinking Water Treatments”, Chemosphere, 2016, 144: 148-153.

Casey Burton, Yongbo Dan, Ariel Donovan, Kun Liu, Honglan Shi, Yinfa Ma, Cynthia P. Bosnak, “Urinary Metallomics as a Novel Biomarker Discovery Platform: Breast Cancer as a Case Study”, Clinica Chimica Acta, 2016, 452: 142–148.

Qingbo Yang, Tien-Sung Lin, Casey Burton, Sungho Park, Yinfa Ma, “Physicochemical insights of irradiation-enhanced hydroxyl radical generation on nano-ZnO surface and its correlation with early-stage cell death”, Toxicology Research, 2016, 5, 482-491..

Yinfa Ma, Sanjeewa Gamagedara, “Biomarker Analysis for Oncology”, Biomarkers in Medicine, 2015, 9:845-850.

Yang, Qingbo, Sisi Chen, Honglan Shi, Hai Xiao, Yinfa Ma, “In vitro Study of Improved Wound-Healing Effect of Bioactive Borate-Based Glass Nano-/Micro-Fibers”. Materials Science & Engineering C, 2015, (55) 105-117.

Qingbo Yang, Hanzheng Wang, Sisi Chen, Xinwei Lan, Hai Xiao, Honglan Shi, Yinfa Ma, “A Novel Fiber-Optic Based Nano-Probe Using Hexagonal 6 -in-1 Fiber Configuration for Intracellular Single-Cell pH Measurement”, Analytical Chemistry, 2015, 87: 7171−7179.

Casey Burton, Rui Weng, Li Yang, Yu Bai, Huwei Liu, Yinfa Ma, “High-throughput intracellular pteridinic profiling by liquid chromatography–quadrupole time-of-flight mass spectrometry”, Analytica Chimica Acta, 2015, 853: 442-450.

Yang, Qingbo, Hanzheng Wang, Xinwei Lan, Baokai Cheng, Sisi Chen, Honglan Shi, Hai Xiao, Yinfa Ma, “Reflection-mode micro-spherical fiber-optic probes for in vitro real-time and single-cell level pH sensing”. The Sensors and Actuators B: Chemical. 2015, 207: 571-580.

Casey Burton, Honglan Shi, and Yinfa Ma, “Normalization of Urinary Pteridines by Urine Specific Gravity for Early Cancer Detection”, Clinica Chimica Acta, 2014, 435, 42-47.

Casey Burton, Honglan Shi, and Yinfa Ma, “Simultaneous Detection of Six Urinary Pteridines and Creatinine by High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Clinical Breast Cancer Detection”, Analytical Chemistry, 2013, 85: 11137−11145.

Qihua Wu, Jeong Tae Ok, Yongpeng Sun, S.T. Retterer, Keith B. Neeves, Xiaolong Yin, Baojun Bai, Yinfa Ma, “Optic imaging of single and two-phase pressure-driven flows in nano-scale channels”, Lab on a Chip, 2013, 13, 1165–1171.

Casey Burton, Sanjeewa Gamagedara, and Yinfa Ma, “Partial enzymatic elimination and quantification of sarcosine from alanine using liquid chromatography–tandem mass spectrometry”, Analytical and Bioanalytical Chemistry, 2013, 405:3153-3158.

Sanjeewa B. Gamagedara, Anthony T. Kaczmarek, Yongqing Jiang, Xiaoling Cheng, Maduka Rupasinghe, Yinfa Ma, “Validation study of urinary metabolites as potential biomarkers for prostate cancer detection”, Bioanalysis, 2012, 4: 1175-1183.

Ruipu Mu, Honglan Shi, Yuan Yuan, Adcharee Karnjanapiboonwong, Joel G. Burken, Yinfa Ma, “A fast separation and quantification method for nitroguanidine and 2,4-dinitroanisole by ultra-fast liquid chromatography-tandem mass spectrometry”, Anal. Chem.  2012, 84 (7): 3427–3432.

Sanjeewa Gamagedara, Honglan Shi, Yinfa Ma, “Quantitative Determination of Taurine and Related Biomarkers in Urine by Liquid Chromatography - Tandem Mass Spectrometry”, Analytical and Bioanalytical Chemistry, 2011, 402:763–770.

Sanjeewa Gamagedara and Yinfa Ma, “Biomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS”, Bioanalysis, 2011, 3(18): 2129–2142.

Chuan Wang, Honglan Shi, Craig D. Adams, Sanjeewa Gamagedara, Isaac Stayton, Terry Timmons, Yinfa Ma, “Occurrence study of pharmaceutical and personal care products in Missouri natural and drinking water using LC-MS/MS”, Water Research, 2010, 45:1818-1828.

Yongqing Jiang, Xiaoliang Cheng, Chuan Wang and Yinfa Ma, “Quantitative Determination of Sarcosine and Related Compounds in Urinary Samples by Liquid Chromatography with Tandem Mass Spectrometry”, Analytical Chemistry, 2010, 82:9022-9027.

Sanjeewa Gamagedara, Stephen Gibbons and Yinfa Ma, “Investigation of Urinary Pteridine Levels as Potential Biomarkers for Non-invasive Diagnosis of Cancer”, Clinica Chimic Acata, 2010, 412:120-128.

Xiaoqian Liu, Philip Whitefield, and Yinfa Ma, “Separation and Quantification of F2-isoprostane Isomers in Cultured Human Lung Epithelial Cells after Silica Oxide and Metal Oxide Nanoparticle Treatment by Liquid Chromatography/Tandem Mass Spectrometry”,  Talanta, 2010, 81:1599-1606. 

Xiaoliang Cheng, Honglan Shi, Craig Adams, Terry Timmons, and Yinfa Ma, “Simultaneous Screening of Herbicide Degradation Byproducts in Water Treatment Plants using High Performance Liquid Chromatography-Tandem Mass Spectrometry”, Journal of Agricultural and Food Chemistry, 2010, 58:4588-4593.

Yongqing Jiang, Yinfa Ma, “A Fast Capillary Electrophoresis Method for Separation and Quantification of Modified Nucleosides in Urinary Samples”, Analytical Chemistry, 2009, 81: 6474–6480.

Isaac Stayton, Jeffrey Winiarz, Katie Shannon, and Yinfa Ma, “Study of Uptake and Loss of Silica Nanoparticles in Living Human Lung Epithelial Cells at the Single Cell Level”, Analytical and Bioanalytical Chemistry, 2009, 394:1595-1608.

Hongwei Gai, Isaac Stayton, Xin Liu, Bingcheng Lin, Yinfa Ma, “Visualizing chemical interactions in life sciences with wide-field fluorescence microscopy towards the single-molecule level”, Trends in Analytical Chemistry, 2007, 26(10): 980-992.

Weisheng Lin, Yue-wern Huang, Xiao-Dong Zhou, and Yinfa Ma, “In Vitro Toxicity of Silica Nanoparticles in Human Lung Cancer Cells”, Toxicology and Applied Pharmacology, 2006, 217, 252-259.

Hongwei Gai, Qi Wang, Yinfa Ma, Bingcheng Lin, “Correlations between molecular numbers and molecular masses in an evanescent field and their applications in probing molecular interactions”, Angewandte Chemie, 2005, 44, 5107-5110.

Hongwei Gai, Ying Li, Zhanhua Silber-Li, Yinfa Ma, Bingcheng Lin, “Simultaneously measurements the velocities of particle/single molecules in bulk flow and near wall flow in microchannel”, Lab on Chip, 2005, 5, 443-449. 

Guanyu Yang, Yinfa Ma, and Jie Xu, “A Biomimetic Catalytic System Driven by Electron Transfer for Selective Oxygenation of Hydrocarbon”, J. Am. Chem. Soc., 2004, 126, 10542-10543.

Guanshu Liu, Junnan Chen, Ping Che and Yinfa Ma, “Separation and Quantitation of Short-Chain Co-Enzyme A in Biological Samples by Capillary Electrophoresis”, Analytical Chemistry, 2003, 75, 78-82.

Yinfa Ma, Michael R. Shortreed, Hanlin Li, Weihua Huang, Edward S. Yeung, “Single-Molecule Immunoassay and DNA diagnosis”, Electrophoresis, 2001, 22, 421-426. 

Yinfa Ma, Michael R. Shortreed and Edward S. Yeung, “High-Throughput Single-Molecule Spectroscopy in Free Solution”, Anal. Chem., 2000, 72, 4640-4645.

Futian Han, Bryan Huynh, Honglan Shi, Bingcheng Lin and Yinfa Ma, “Pteridine Analysis in Urine by Capillary Electrophoresis Using Laser-Induced Fluorescence Detection”, Anal. Chem., 1999, 71, 1265-1269.