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V. Prakash Reddy
341 Schrenk Hall
Missouri University of Science and Technology
Rolla, MO 65409-0010
Case Western Reserve University, Ph.D., 1986.
Syracuse University (Thermal Pericyclic Reactions)
University of Southern California (Carbocations and Synthetic Organofluorine Chemistry)
Our research interests are diverse and interdisciplinary, ranging from carbocation reaction mechanisms to organofluorine chemistry, environmentally benign ("green") chemistry, protein modifications and asymmetric Friedel-Crafts reactions. This can be applied to drug design, understanding mechanisms of the aging process, and environmentally safe destruction of surplus chemical warfare agent stockpiles and other hazardous chemical materials.
SELECTED RECENT PUBLICATIONS
Adrian Sieradzki, Bharat B. Yendluri, Hector H. Palacios, Kalpana Parvathaneni, V. Prakash Reddy, Mark E. Obrenovich, Kazimierz Gasiorowski, Jerzy Leszek, Gjumrakch Aliev, "Implication of oncogenic signaling pathways as a treatment strategy for neurodegenerative disorders - contempory approaches", CNS & Neruological Disorders: Drug Targets, 10, 175-183 (2011).
Nanditha Nair, Wataru Kudo, Mark A. Smith, Ravinder Abrol, William A. Goddard III, V. Prakash Reddy, "Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: Synthesis, neuronal cell culture investigations, and CDK5 docking studies", Bioorganic & Medicinal Chemistry Letters, 21, 3957-3961 (2011).
Mark E. Obrenovich, Nanditha G. Nair, Ayse Beyaz, Gjumrakch Aliev and V. Prakash Reddy, "The Role of Polyphenolic Antioxidants in Health, Disease, and Aging," Rejuvenation Research, 13, 631-643 (2010).
Nanditha G. Nair, George Perry, Mark A. Smith and V. Prakash Reddy, "NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide," Journal of Alzheimer's Disease, 20, 57-66 (2010).
Gjumrakch Aliev and V. Prakash Reddy, "Oxidative Stress-induced Cellular Hypoperfusion, Mitochondrial Failure and Brain Hypometabolism as the Causative Factors for the Pathophysiology of Cerebrovascular and Alzheimer Disease: Past, Present and Future," Ben Sci. (Highlights), 2, 1-4 (2010).
V. Prakash Reddy, George Perry and Mark A. Smith, "Brain Composition: Age-Related Changes," Handbook of the Neuroscience of Aging, Eds. P. R. Hof and C. V. Mobbs, Elsevier, 39-42 (2009).
V. Prakash Reddy and G. K. Surya Prakash, "Recent studies of persistent carbodications," Advances in Physical Organic Chemistry, 43, 219-260 (2009).
Nanditha G. Nair, Mario Blanco, William West, F. Christoph Weise, Steve Greenbaum, V. Prakash Reddy, "Fluorinated Boroxin-Based Anion Receptors for Lithium Ion Batteries: Fluoride Anion Binding, Ab Initio Calculations, and Ionic Conductivity Studies," Journal of Physical Chemistry A, 113, 5918-5926 (2009).
Angelika Bierhaus, V. Prakash Reddy, Xiongwei Zhu, George Perry, Mark A. Smith, "Oxidative Stress in Diabetes and Alzheimer's Disease," Journal of Alzheimer's Disease, 16, 763-774 (2009).
Gjumrakch Aliev, Mark E. Obrenovich, V. Prakash Reddy, Justin C. Shenk, Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith, George Perry, "Antioxidant therapy in Alzheimer's disease: theory and practice," Mini-Reviews in Medicinal Chemistry, 8, 1395-1406 (2008).
Stephanie Velez, Nanditha G. Nair, V. Prakash Reddy, "Transition metal ion binding studies of carnosine and histidine: Biologically relevant antioxidants," Colloids and Surfaces, B: Biointerfaces, 66, 291-294 (2008).
Ramesh Alleti, Woon Su Oh, Meher Perambuduru, C. V. Ramana, V. Prakash Reddy, "Imidazolium-based polymer supported gadolinium triflate as a heterogeneous recyclable Lewis acid catalyst for Michael additions," Tetrahedron Letters, 49, 3466-3470 (2008).