Nuran Ercal

Richard K. Vitek/FCR Endowed Chair in Biochemistry

234 Schrenk Hall
Missouri University of Science and Technology
Rolla, MO 65409-0010
(573) 341-6950

Hacettepe University, Ph.D., 1990.

Instanbul Medial Faculty, MD, 1981

Personal Webpage  



Biochemistry, Medicinal Chemistry.

Research Interests

Analytical Biochemistry, metal-toxicity, free radicals in biological systems





Tobwala, S., Zhang, X., Zheng, Y., Wang, H. J., Banks, W. A., and Ercal, N. (2013) Disruption of the integrity and function of brain microvascular endothelial cells in culture by exposure to diesel engine exhaust particles, Toxicology letters220, 1-7.

Tobwala, S., Fan, W., Stoeger, T., and Ercal, N. (2013) N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549), Free radical research47, 740-749.

Tian, F., Habel, N. C., Yin, R., Hirn, S., Banerjee, A., Ercal, N., Takenaka, S., Estrada, G., Kostarelos, K., Kreyling, W., and Stoeger, T. (2013) Pulmonary DWCNT exposure causes sustained local and low-level systemic inflammatory changes in mice, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V84, 412-420.

Shah, G. N., Price, T. O., Banks, W. A., Morofuji, Y., Kovac, A., Ercal, N., Sorenson, C. M., Shin, E. S., and Sheibani, N. (2013) Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis, The Journal of pharmacology and experimental therapeutics344, 637-645.

Atabek Yigit, E., and Ercal, N. (2013) Release of N-acetylcysteine and N-acetylcysteine amide from contact lenses, Eye & contact lens39, 335-340.

Zhang, X., Tobwala, S., and Ercal, N. (2012) N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice, Human & experimental toxicology31, 931-944.

Price, T. O., Eranki, V., Banks, W. A., Ercal, N., and Shah, G. N. (2012) Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice, Endocrinology153, 362-372.

Mayo, J. N., Beard, R. S., Jr., Price, T. O., Chen, C. H., Erickson, M. A., Ercal, N., Banks, W. A., and Bearden, S. E. (2012) Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism32, 825-834.

Farr, S. A., Price, T. O., Dominguez, L. J., Motisi, A., Saiano, F., Niehoff, M. L., Morley, J. E., Banks, W. A., Ercal, N., and Barbagallo, M. (2012) Extra virgin olive oil improves learning and memory in SAMP8 mice, Journal of Alzheimer's disease : JAD28, 81-92.

Farr, S. A., Price, T. O., Banks, W. A., Ercal, N., and Morley, J. E. (2012) Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice, Journal of Alzheimer's disease : JAD32, 447-455.

Chen, W., Ercal, N., Huynh, T., Volkov, A., and Chusuei, C. C. (2012) Characterizing N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) binding for lead poisoning treatment, Journal of colloid and interface science371, 144-149.

Winkler, A., Njalsson, R., Carlsson, K., Elgadi, A., Rozell, B., Abraham, L., Ercal, N., Shi, Z. Z., Lieberman, M. W., Larsson, A., and Norgren, S. (2011) Glutathione is essential for early embryogenesis--analysis of a glutathione synthetase knockout mouse, Biochemical and biophysical research communications412, 121-126.

Schimel, A. M., Abraham, L., Cox, D., Sene, A., Kraus, C., Dace, D. S., Ercal, N., and Apte, R. S. (2011) N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation, The American journal of pathology178, 2032-2043.

Penugonda, S., and Ercal, N. (2011) Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice, Toxicology letters201, 1-7.

Manda, K. R., Banerjee, A., Banks, W. A., and Ercal, N. (2011) Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells, Free radical biology & medicine50, 801-810.

Chen, J., Mercer, G., Roth, S. R., Abraham, L., Lutz, P., Ercal, N., and Neal, R. E. (2011) Sub-chronic lead exposure alters kidney proteome profiles, Human & experimental toxicology30, 1616-1625.

Carey, J. W., Pinarci, E. Y., Penugonda, S., Karacal, H., and Ercal, N. (2011) In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide, Free radical biology & medicine50, 722-729.

Beyerle, A., Braun, A., Banerjee, A., Ercal, N., Eickelberg, O., Kissel, T. H., and Stoeger, T. (2011) Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice, Biomaterials32, 8694-8701.

Banks, W. A., Morley, J. E., Farr, S. A., Price, T. O., Ercal, N., Vidaurre, I., and Schally, A. V. (2010) Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice, Proceedings of the National Academy of Sciences of the United States of America107, 22272-22277.

Banerjee, A., Zhang, X., Manda, K. R., Banks, W. A., and Ercal, N. (2010) HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide, Free radical biology & medicine48, 1388-1398.

Zhang, X., Banerjee, A., Banks, W. A., and Ercal, N. (2009) N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells, Brain research1275, 87-95.

Shi, R., Huang, C. C., Aronstam, R. S., Ercal, N., Martin, A., and Huang, Y. W. (2009) N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes, BMC pharmacology9, 7.

Banerjee, A., Trueblood, M. B., Zhang, X., Manda, K. R., Lobo, P., Whitefield, P. D., Hagen, D. E., and Ercal, N. (2009) N-acetylcysteineamide (NACA) prevents inflammation and oxidative stress in animals exposed to diesel engine exhaust, Toxicology letters187, 187-193.

Ates, B., Ercal, B. C., Manda, K., Abraham, L., and Ercal, N. (2009) Determination of glutathione disulfide levels in biological samples using thiol-disulfide exchanging agent, dithiothreitol, Biomedical chromatography : BMC23, 119-123.