Nuran Ercal

Richard K.Vitek/FCR Endowed Chair in Biochemistry

234 Schrenk Hall
Missouri University of Science and Technology
Rolla, MO 65409-0010
(573) 341-6950

Hacettepe University, Ph.D., 1990.

Istanbul Medical Faculty, MD, 1981.

Personal Webpage  



Biochemistry, Medicinal Chemistry.

  • Biological thiols
  • Thiol detection by HPLC in biological samples
  • Oxidative stress related disorders 
  • Effects of a novel thiol antioxidant on oxidative stress related disorders







Tobwala S, Zhang X, Zheng Y, Wang HJ, Banks WA, Ercal N, “Disruption of the Integrity and Function of Brain Microvascular Endothelial Cells in Culture by Exposure to Diesel Engine Exhaust Particles,” ToxicolLett, 220: 1-7, 2013.

Tobwala S, Weili M, Stoeger T, Ercal N, “N-Acetylcysteine amide (NACA), a Thiol Antioxidant, Prevents Bleomycin-Induced Toxicity in Human Alveolar Basal Epithelial Cells (A549),” Accepted for  Free Radical Research, 47 (9), 740-749, 2013.

Farr SA, Price TO, Banks WA, Ercal N, Morley JE, “Effect of Alpha-Lipoic Acid on Memory, Oxidation, and Lifespan in SAMP8 Mice,” J Alzheimers Dis, 32(2):447-55, doi: 10.3233/JAD-2012-12013,2013.

Shah GN, Price TO, Banks WA, Morofuji Y, Kovac A, Ercal N, “Pharmacological Inhibition of Mitochondrial Carbonic Anhydrases Protects Mouse Cerebral Pericytes from High Glucose-Induced Oxidative Stress and Apoptosis,” J PharmacolExpTher, 344(3):637-45, doi: 10.1124/jpet.112.201400. Epub 2012 Dec 17, 2013.

Tian F, Habel NC, Yin R, Hirn S, Banerjee A, Ercal N, Takenaka S, Estrada G, Kostarelos K, Kreyling W, Stoeger T, “Pulmonary DWCNT Exposure Causes Sustained Local and Low-Level Systemic Inflammatory Changes in Mice,” Eur J Pharm Biopharm,doi:pii: S0939-6411(13)00096-9. 10.1016/j.ejpb.2013.03.008. Epub ahead of print 2013.

Mayo JN, Beard RS Jr, Price TO, Chen CH, Eickson MA, Ercal N, Banks WA, Bearden SE, “Nitrative Stress in Cerebral Endothelium is Mediated by mGluR5 in Hyperhomocysteinemia.” J Cereb Blood Flow Metab, 32 (5): 825-834, 2012.

Farr SA, Price TO, Dominguez LJ, Motisi A, Saiano F, Niehoff ML, Morley JE, Banks WA, Ercal N, Barbagallo M, “Extra Virgin Olive Oil Improves Learning and Memory in SAMP8 Mice.” J Alzheimers Dis, 28(1): 81-92, 2012.

Chen W, Ercal N,Huynh T, VolkovA, and Chusuei CC, “Characterizing N-acetylcysteine (NAC) and N-acetylcysteine Amide (NACA) Binding for Lead Poisoning Treatment.”J Colloid Interface Sci, 371(1):144-149,2012.

Price TO, Eranki V, Banks WA, Ercal N, Shah GN, “Topiramate Treatment Protects Blood-Brain Barrier Pericytes from Hyperglycemia-Induced Oxidative Damage in Diabetic Mice.” Endocrinology, 153(1):362-72, 2012.

Carey WJ, Tobwala S, Zhang X, Banerjee A, Ercal N, Pinarci EY, Karacal H, “N-Acetylcysteine Amide Protects Against Methamphetamine-Induced Oxidative Stress in Retinal Pigment Epithelial Cells,” J of Biophysical Chemistry, 3(2):101-110, 2012.

Zhang X, Tobwala S, Ercal N, “N-Acetylcysteine Amide Protects Against Methamphetamine-Induced Tissue Damage in CD-1 Mice.” Hum ExpToxicol, 31(9):931-44, 2012.

Demirkol O, Zhang X and Ercal N, “Oxidative Effects of Tartrazine (CAS No. 1934-21-0 and New Coccin (CAS No. 2611-82-7) Azo Dyes on CHO Cells,” J Consumer Protection and Food Safety 7:229-236, 2012.

Carey JW, Pinarci EY, Penugonda S, Karacal H, Ercal N, “In Vivo Inhibition of L-Buthionine-(S,R)-Sulfoximine-Induced Cataracts by a Novel Antioxidant, N-Acetylcysteine Amide.” Free RadicBiol Med, 50(6):722-729, 2011. 

Penugonda S, Ercal N, “Comparative Evaluation of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) on Glutamate and lead-Induced Toxicity in CD-1 Mice,” ToxicolLett, 25;201(1):1-7, 2011.

Chen J, Mercer G, Roth SR, Abraham L, Lutz P, Ercal N, Neal RE, “Sub-chronic Lead Exposure Alters Kidney Proteome Profiles.” Hum ExpToxicol, 30(10):1616-1625, 2011. 

Schimel A, Abraham L, Cox D, Sene A, Kraus C,  Dace DS, Ercal N, Apte RS, “N-acetylcysteine Amide (NACA) Prevents Retinal Degeneration by Up-Regulating Reduced Glutathione Production and Reversing Lipid Peroxidation.” Am J Pathol, 178(5):2032-2043, 2011.

Winkler A, Njålsson R, Carlsson K, Elgadi A, Rozell B, Abraham L, Ercal N, Shi ZZ, Lieberman MW, Larsson A, Norgren S, “Glutathione is Essential for Early Embryogenesis - Analysis of a Glutathione Synthetase Knockout Mouse.” BiochemBiophys Res Commun,412(1):121-126, 2011.

Beyerle A, Braun A, Banerjee A, Ercal N, Eickelberg O, Kissel TH, Stoeger T, “Inflammatory Responses to Pulmonary Application of PEI-Based SiRNANanocarriers in Mice.” Biomaterials, 32(33): 8694-8701, 2011.

Banerjee A, Zhang X, Manda KR, Banks WA, Ercal N, “HIV Proteins (gp120 and Tat) and Methamphetamine in Oxidative Stress-Induced Damage in the Brain: Potential Role of the Thiol Antioxidant N-Acetylcysteine Amide.” Free RadicBiol Med, 48(10):1388-1398, 2010. 

Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV, “Effects of a Growth Hormone-Releasing Hormone Antagonist on Telomerase Activity, Oxidative Stress, Longevity, and Aging in Mice,” ProcNatlAcadSci USA, 107(51):22272-22277, 2010.

Manda KR, Banerjee A, Banks WA, Ercal N, “Highly Active AntiretroviraL Therapy Drug Combination Induces Oxidative Stress and Mitochondrial Dysfunction in Immortalized Human Blood-Brain Barrier Endothelial Cells.” Free RadicBiol Med, 50(7): 801-810, 2010.

Ates B, Ercal BC, Manda K, Abraham LS, Ercal N, “Determination of Glutathione Disulfide Levels in Biological Samples Using Thiol-disulfide Exchanging Agent, Dithiothreitol (DTT).”Biomed Chromatogr, 23(2):119-123, 2009.

Shi R, Huang CC, Aronstam RS, Ercal N, Martin A, Huang YW, “N-AcetylcysteineAmide Decreases Oxidative Stress But Not Cell Death Induced by Doxorubucin in H9c2 Cardiomyocytes.” BMC Pharmacol, 15:9:7, 2009. 

Zhang X, Banerjee A, Banks WA, Ercal N, “N-Acetylcysteine Amide Protects Against Methamphetamine-Induced Oxidative Stress and Neurotoxicity in Immortalized Human Brain Endothelial Cells.” Brain Res, 1275: 87-95, 2009. 

Banerjee A, Trueblood MB, Zhang X, Manda KR, Lobo P, Whitefield PD, Hagen DE, Ercal N, “N-Acetylcysteine Amide (NACA) Prevents Inflammation and Oxidative Stress in Animals Exposed to Diesel Engine Exhaust.” ToxicolLett. 187(3):187-193, 2009. 

Matthews RH, Kadoch C, Ercal N, “Alcohol as a Potential Contributing Factor in Radiation Complications.” ClinAdvHematolOncol. Apr; 7(4):257-262, 2009. 

Ogony J, Matthews RH, Anni H, Shannon K, Ercal N, “The Mechanism of Elevated Toxicity in HepG2 Cells Due to Combined Exposure to Ethanol and Ionizing Radiation.” J ApplToxicol, 28(3):345-355, 2008. 

Ates B, Abraham L, Ercal N, “Antioxidant and Free Radical Scavenging Properties of N-Acetylcysteine Amide (NACA) and Comparison with N-Acetylcysteine (NAC).” Free Radic Res, 42(4):372-377, 2008. 

Wu W, Abraham LS, Ogony J, Matthews RH, Ercal N, “Effects of N-Acetylcysteine Amide (NACA), a Thiol Antioxidant on Radiation Induced Cytotoxicity in Chinese Hamster Ovary cells.” Life Sci, 82(21-22):1122-1130, 2008. 

Demirkol O, Cagri-Mehmetoglu A, Qiang Z, Ercal N, Adams C, “Impact of Food Disinfection on Beneficial Biothiol Contents in Strawberry” J AgricFoodChem, 56(21):10414-10421, 2008.